Prof. Dr. Thorsten Hugel

Projects within livMatS

• Theoretical modeling of nonequilibrium chemical fueling, self-regulation, and the multi-stimuli response and adaptation of hydrogel-based materials
• Chemically fueled driven adaptivity in materials systems (H2O2-O2-fueled Adaptivity)
• NANOTRET: Nano‐micro‐structured permanently charged surfaces for electret nanogenerators
• Hierarchically Programmable Materials with Propagating Stimulus Responsive Elements and Metamaterial Ultrastructuring
• Training Materials like Muscles
• Interfaces, charge-transfer and non-adiabatic processes and their exploitation in a frequency-tunable tribogenerator
• Dissipative systems engineering: Chemically fueled active molecular systems
• Logic Self-Reporting Mechano-Adaptive Metamaterials
  
  

Doctoral Researchers (first supervisor)

• Christiane Wenzel

Completed Doctoral Researchers (first supervisor)

• Dr. Qiwei Hu
• Dr. Max Lallemang
  
  

Publications in livMatS

• Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds*
  Lallemang, M., Akintayo, C. O., Wenzel, C., Chen, W., Sielaff, L., Ripp, A., Jessen, H. J., Bizan N., Walther, A. & Hugel, T. (2023). Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds. ACS Applied Materials & Interfaces. doi: 10.1021/acsami.3c15135
• Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes*
  Dai, K., Pol, M. D., Saile, L., Sharma, A., Liu, B., Thomann, R., Trefs, J. L., Qiu, D., Moser, S., Wiesler, S., Balzer, B., Hugel, T., Jessen, H. J. & Pappas, C. G. (2023). Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes. <i<Journal of the American Chemical Society. doi: 10.1021/jacs.3c07918
• Anisotropic Friction in a Ligand-Protein Complex*
  Cai, W., Jäger, M., Bullerjahn, J. T., Hugel, T., Wolf, S., & Balzer, B. N. (2023). Anisotropic Friction in a Ligand-Protein Complex. Nano Letters. doi: 10.1021/acs.nanolett.2c04632
• Anisotropy of π–π Stacking as Basis for Superlubricity*
  Cai, W., Trefs, J. L., Hugel, T., & Balzer, B. N. (2022). Anisotropy of π–π Stacking as Basis for Superlubricity. ACS Materials Letters, 5, 172-179. doi: 10.1021/acsmaterialslett.2c00974
• The articular cartilage surface is impaired by a loss of thick collagen fibers and formation of type I collagen in early osteoarthritis*
  Tschaikowsky, M., Brander, S., Barth, V., Thomann, R., Rolauffs, B., Balzer, B. N., & Hugel, T. (2022). The articular cartilage surface is impaired by a loss of thick collagen fibers and formation of type I collagen in early osteoarthritis. Acta Biomaterialia. doi: 10.1016/j.actbio.2022.04.036
• Angle-dependent strength of a single chemical bond by stereographic force spectroscopy*
  Cai, W., Bullerjahn, J. T., Lallemang, M., Kroy, K., Balzer, B. N., & Hugel, T. (2022). Angle-dependent strength of a single chemical bond by stereographic force spectroscopy. Chemical Science. doi: 10.1039/D2SC01077A
• Multivalent non-covalent interactions lead to strongest polymer adhesion*
  Lallemang, M., Yu, L., Cai, W., Rischka, K., Hartwig, A., Haag, R., Hugel, T., and Balzer, B. N. (2022). Multivalent non-covalent interactions lead to strongest polymer adhesion. Nanoscale. doi: 10.1039/d1nr08338d
• Inside a Shell – Organometallic Catalysis Inside Encapsulin Nanoreactors*
  Lohner, P., Zmyslia, M., Thurn, J., Pape, J. K., Gerasimaite, R., Keller-Findeisen, J., Groeer, S., Deuringer, B., Süss, R., Walther, A., Hell, S. W., Lukinavicius, G., Hugel, T., & Jessen-Trefzer, C. (2021). Inside a Shell–Organometallic Catalysis Inside Encapsulin Nanoreactors. Angewandte Chemie. doi: 10.1002/anie.202110327
• Hybrid fluorescence-AFM explores articular surface degeneration in early osteoarthritis across length scales*
  Tschaikowsky, M., Neumann, T., Brander, S., Haschke, H., Rolauffs, B., Balzer, B. N., & Hugel, T. (2021). Hybrid fluorescence-AFM explores articular surface degeneration in early osteoarthritis across length scales. Acta Biomaterialia. doi: 10.1016/j.actbio.2021.03.034
• Proof-of-concept for the detection of early osteoarthritis pathology by clinically applicable endomicroscopy and quantitative AI-supported optical biopsy*
  Tschaikowsky, M., Selig, M., Brander, S., Balzer, B. N., Hugel, T., & Rolauffs, B. (2020). Proof-of-concept for the detection of early osteoarthritis pathology by clinically applicable endomicroscopy and quantitative AI-supported optical biopsy. Osteoarthritis and cartilage. doi: 10.1016/j.joca.2020.10.003
• ATP Impedes the Inhibitory Effect of Hsp90 on Aβ40 Fibrillation*
  Wang, H., Lallemang, M., Hermann, B., Wallin, C., Loch, R., Blanc, A., Balzer, B. N., Hugel, T., & Luo, J. (2020). ATP impedes the inhibitory effect of Hsp90 on Aβ40 fibrillation. Journal of Molecular Biology. doi: 10.1016/j.jmb.2020.11.016
• Covalent Attachment of Single Molecules for AFM-based Force Spectroscopy*
  Kolberg, A., Wenzel, C., Hugel, T., Gallei, M., & Balzer, N. (2020). Covalent Attachment of Single Molecules for AFM-based Force Spectroscopy. JoVE (Journal of Visualized Experiments), (157), e60934. doi:10.3791/60934
• Opposing Temperature Dependence of the Stretching Response of Single PEG and PNiPAM Polymers*
  Kolberg, A., Wenzel, C., Hackenstrass, K., Schwarzl, R., Rüttiger, C., Hugel, T., Gallei, M., Netz, R. R., & Balzer, B. N. (2019). Opposing temperature dependence of the stretching response of single PEG and PNiPAM polymers. Journal of the American Chemical Society, 141(29), 11603-11613. doi: 10.1021/jacs.9b04383
  
  
  * Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy – EXC-2193/1 – 390951807