People
Prof. Dr. Henning Jessen
Coordinator Research Area B
Principal Investigator Research Areas B and C
Full Professor, Bioorganic Chemistry
Faculty of Chemistry and Pharmacy | Institute for Organic Chemistry
University of Freiburg
Phone: +49 761 203 6073
Email: henning.jessen@oc.uni-freiburg.de
Areas of Expertise
Chemical biology | Phosphate homeostasis | Inorganic polyphosphate | Nucleotides | Inositol pyrophosphates
Projects within livMatS
- From Phase Separation to Living Materials
- Chemically fueled driven adaptivity in materials systems (H2O2-O2-fueled Adaptivity)
- Dissipative systems engineering: Chemically fueled active molecular systems
- Logic Self-Reporting Mechano-Adaptive Metamaterials
Doctoral Researchers (first supervisor)
Completed Doctoral Researchers (first supervisor)
Publications in livMatS
- The P(III)-amidite based synthesis of stable isotope labeled mRNA-cap-structures enables their sensitive quantitation from brain tissue* (early access)
Ripp, A., Krämer, M., Barth, V., Moser, P., Haas, T. M., Singh, J., Huck, T., Gleue, L., Friedland, K., Helm, M., & Jessen, H. J. (2024). The P(III)-amidite based synthesis of stable isotope labeled mRNA-cap-structures enables their sensitive quantitation from brain tissue.
Angewandte Chemie International Edition, e202414537. doi: 10.1002/anie.202414537 - Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds*
Lallemang, M., Akintayo, C. O., Wenzel, C., Chen, W., Sielaff, L., Ripp, A., Jessen, H. J., Bizan N., Walther, A. & Hugel, T. (2023). Hierarchical Mechanical Transduction of Precision-Engineered DNA Hydrogels with Sacrificial Bonds. ACS Applied Materials & Interfaces. doi: 10.1021/acsami.3c15135 - Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes*
Dai, K., Pol, M. D., Saile, L., Sharma, A., Liu, B., Thomann, R., Trefs, J. L., Qiu, D., Moser, S., Wiesler, S., Balzer, B., Hugel, T., Jessen, H. J. & Pappas, C. G. (2023). Spontaneous and Selective Peptide Elongation in Water Driven by Aminoacyl Phosphate Esters and Phase Changes. <i<Journal of the American Chemical Society. doi: 10.1021/jacs.3c07918 - Non-Hydrolysable Analogues of Cyclic and Branched Condensed Phosphates: Chemistry and Chemical Proteomics*
Dürr-Mayer, T., Schmidt, A., Wiesler, S., Huck, T., Mayer, A., & Jessen, H. J. (2023). Non‐Hydrolysable Analogues of Cyclic and Branched Condensed Phosphates: Chemistry and Chemical Proteomics. Chemistry–A European Journal, e202302400. doi: 10.1002/chem.202302400 - Beyond Triphosphates: Reagents and Methods for Chemical Oligophosphorylation*
Shepard, S. M., Jessen, H. J., & Cummins, C. C. (2022). Beyond Triphosphates: Reagents and Methods for Chemical Oligophosphorylation. Journal of the American Chemical Society. doi: 10.1021/jacs.1c07990 - The aryne phosphate reaction*
Haas, T., Wiesler, S., Dürr-Mayer, T., Ripp, A., Fouka, P., Qiu, D., & Jessen, H. (2021). The Aryne Phosphate Reaction. Angewandte Chemie. doi: 10.1002/ange.202113231 - Lost in Condensation: Poly-, Cyclo-, and Ultraphosphates*
Jessen, H. J., Dürr-Mayer, T., Haas, T. M., Ripp, A., & Cummins, C. C. (2021). Lost in Condensation: Poly-, Cyclo-, and Ultraphosphates. Accounts of Chemical Research. doi: 10.1021/acs.accounts.1c00370 - The Aryne Phosphate Reaction*
Haas, T., Wiesler, S., Dürr-Mayer, T., Ripp, A., Fouka, P., Qiu, D., & Jessen, H. (2021). The Aryne Phosphate Reaction. ChemRxiv. doi: 10.33774/chemrxiv-2021-3mfj8 - The chemistry of branched condensed phosphates*
Dürr-Mayer, T., Qiu, D., Eisenbeis, V. B., Steck, N., Häner, M., Hofer, A., Mayer, A., Siegel, J. S., Baldridge, K. K., & Jessen, H. J.(2021). The chemistry of branched condensed phosphates. Nature Communications, 12(1), 1-11. doi: 10.1038/s41467-021-25668-3 - Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties*
Ma, J., Ripp, A., Wassy, D., Dürr, T.,Qiu, D., Häner, M., Haas, T., Popp, C., Bezold, D., Richert, S., Esser, B., Jessen, H. J. (2020). Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties. Molecules, 25(22), 5325. doi: 10.3390/molecules25225325 - Rapid Synthesis of Nucleoside Triphosphates and Analogues*
Ripp, A., Singh, J., & Jessen, H. (2020). Rapid Synthesis of Nucleoside Triphosphates and Analogues. Current Protocols in Nucleic Acid Chemistry, 81(1), e108. doi: 10.1002/cpnc.108 - Multiple Light Control Mechanisms in ATP‐fueled Non‐Equilibrium DNA Systems*
Deng, J., Bezold, D., Jessen, H., & Walther, A. (2020). Multiple Light Control Mechanisms in ATP‐Fueled Non‐equilibrium DNA Systems. Angewandte Chemie International Edition. doi: 10.1002/anie.202003102 - Cyclotriphosphate: A Brief History, Recent Developments, and Perspectives in Synthesis*
Bezold, D., Dürr, T., Singh, J., & Jessen, H. J. (2020). Cyclotriphosphate: A brief history, recent developments, and perspectives in synthesis. Chemistry–A European Journal, 26(11), 2298-2308. doi: 10.1002/chem.201904433 - Synthesis of Modified Nucleoside Oligophosphates Simplified: Fast, Pure, and Protecting Group Free*
Singh, J., Ripp, A., Haas, T. M., Qiu, D., Keller, M., Wender, P. A., Siegel, J. S., Baldridge, K. K., & Jessen, H. J. (2019). Synthesis of modified nucleoside oligophosphates simplified: Fast, pure, and protecting group free. Journal of the American Chemical Society, 141(38), 15013-15017. doi: 10.1021/jacs.9b08273
* Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy – EXC-2193/1 – 390951807